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Beyond Weight Loss: How GLP‑1 Medications can Affect the Mind and Body

May 16, 2026
Beyond Weight Loss: How GLP‑1 Medications can Affect the Mind and Body

What happens in the mind—not just the body—when someone starts a GLP‑1 medication?

In this episode, we explore what’s happening in the brain and body when someone takes a GLP‑1, including changes in appetite, metabolism, and what many patients describe as a reduction in “food noise.” We look closely at the psychological impacts clinicians are noticing: shifts in self‑esteem, social experiences around food, and the emotional relief that can come when long‑standing weight struggles finally feel more manageable.

We also discuss important considerations, such as body image, eating disorder history, and what can happen emotionally if someone stops taking a GLP‑1 medication. 

Joseph Fondriest, MD

MEET THE GUEST

Joseph Fondriest, MD

Dr. Joseph Fondriest completed his psychiatry residency at Cleveland Clinic Akron General / Summa Health where he served as chief resident and psychiatry representative for resident staff council. He received his medical degree from Northeast Ohio Medical University, and his bachelor’s degree and computer science minor from Miami University. He specializes in treating mood disorders, anxiety disorders, PTSD, OCD, and personality disorders. He places a heavy emphasis on listening closely to patients. He utilizes a team-based approach to mental healthcare, working alongside patients and their therapists. He treats adults of age 18-64.
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