The Future of Depression Medication 60 Years After Prozac®

New Depression Medications Bring a New Dawn to Treatment

60 years ago, Prozac brought a seismic shift in Depression treatment, shining a new ray of hope into millions of lives. Today, we stand at the threshold of another breakthrough – a new throng of antidepressants, promising yet another transformative shift in mental health care. Welcome to a new era of hope and recovery.

Then and Now – From Prozac to Auvelity®, Spravato® and Zulresso®

The percentage of U.S. adults who report having been diagnosed with depression at some point in their lifetime has reached 29.0%, nearly 10 percentage points higher than in 2015 according to the research conducted by Gallup. The percentage of Americans who are currently being treated for depression has also increased to 17.8%, up roughly seven points over the same period. Both rates are the highest recorded by Gallup since it began measuring depression using the current form of data collection in 2015.

The quest for effective depression treatments has been an arduous journey, marked by scientific rigor, diligent exploration, and relentless pursuit of better patient outcomes. As we navigated through the labyrinth of the human mind, the nuances of mental health continually propelled us to dig deeper, understand better, and seek more efficient solutions.

Years of research led to the advent of Prozac, a drug that reshaped the course of mental health treatment. However, the realization that one drug could not cater to the multifaceted nature of Depression Medication Management spurred the search for more targeted treatments. This necessity became the mother of innovation, leading to the development of drugs like Auvelity, Spravato and Zulresso.

Every step of this journey reinforced the need for personalized treatments acknowledging that every person’s struggle with Depression is unique.

For those struggling with moderate to severe Postpartum Depression, a new and rapidly acting medication is available called Zulresso. Zulresso was FDA approved in 2019 and is the first treatment specifically approved for postpartum depression. Unlike traditional antidepressants, it works very quickly to treat depression by increasing the levels of a naturally occurring hormone in the brain called allopregnanolone.

Spravato (esketamine) has brought new hope for people with Treatment-Resistant Depression (TRD). Prior to the approval of Spravato by the FDA in 2019,, there were limited options available for people who did not respond adequately to multiple antidepressant medications.

Clinical trials have demonstrated that Spravato can lead to a rapid reduction in depressive symptoms. Many patients reported experiencing improvement within hours or days after administration. This fast-acting nature of Spravato is particularly beneficial for individuals who are in urgent need of relief, such as those experiencing severe depression or suicidal thoughts.

For people who suffer from Major Depressive Disorder (MDD), a new rapid action oral antidepressant Auvelity offers a unique approach due to its unique dual action efficacy formula.  MDD is a is a severe, chronic, debilitating mood disorder, characterized by depression, inability to feel pleasure, feelings of guilt and worthlessness, low energy, and other mental and physical symptoms, as well as impairments in social, occupational, educational. or other essential functioning. The major difference between Auvelity and the current roster of antidepressants on the market is its ability to work quickly. While the typical response time for current antidepressants is four to six weeks or longer,

Embracing the Future with Personalized Mental Health Medicine

The advent of new Depression medications like Auvelity signifies a promising stride towards personalized medicine, a future where treatments are adjusted and optimized based on an individual’s unique biochemical makeup. This approach is a stark departure from the ‘one size fits all’ philosophy that often dominates conventional treatment methods.

In the realm of mental health, personalized medicine holds immense potential. It acknowledges the intricate interplay of genetic, environmental, and lifestyle factors that can influence mental health conditions like Depression. This holistic understanding can guide the development of medications designed to target individual-specific factors, enhancing treatment efficacy, and reducing adverse effects.

As we move forward, the crux of mental health treatment will be understanding individual variations in Depression and corresponding responses to medications. This heralds a future where each individual receives a treatment regimen tailored to their needs, fostering improved mental health outcomes.

Barriers to Access in the Road Ahead

While the development of new Depression medication is indeed a remarkable stride, it is essential to recognize the challenges that remain in making these treatments accessible to all who need them. Inequities in healthcare access and affordability continue to hinder many individuals from obtaining effective treatments.

Insurance coverage, high costs of medications, and lack of awareness about the newest treatments for Depression can prevent individuals from getting the care they need. Additionally, the stigma surrounding mental health treatment is a pervasive barrier to access. The fear of judgment or discrimination often deters individuals from seeking help, leaving their conditions untreated.

Ensuring everyone can benefit from advancements in Depression treatments requires concerted efforts to dismantle these barriers. These include advocating for mental health parity in insurance coverage, implementing pricing reforms for medications, increasing mental health literacy, and fostering a society-wide culture of empathy and understanding towards mental health issues.

Overcoming these hurdles is a collective responsibility. Together, we can ensure that the dawn of new Depression medication translates into enhanced mental health outcomes for all.


  • A new generation of antidepressants offers renewed hope for individuals battling depression, particularly those who have found little relief with traditional treatments.
  • Auvelity represents a shift towards more personalized care in depression treatment, targeting neural pathways differently and aiming to reduce the side effects commonly associated with older medications.
  • The approval of Auvelity by the FDA was the result of rigorous testing and clinical trials, solidifying its potential effectiveness in improving the mental health outcomes of individuals with depression.
  • Future depression treatments will focus on personalized medicine, moving away from a “one size fits all” approach and optimizing treatments based on individual biochemical make-up.
  • Battling barriers to access is essential to ensure these advancements are available to all who need them.

Authored By 

LifeStance Health
LifeStance Health

LifeStance is a mental healthcare company focused on providing evidence-based, medically driven treatment services for children, adolescents, and adults suffering from a variety of mental health issues in an outpatient care setting, both in-person and through its digital health telemedicine offering.